We are asking for your help to be able to do a Whole Genome Sequencing of the DNA of a border terrier with idiopathic cramping episodes / fits. Cramping episodes are a common problem in the breed. A gene defect could not yet be found. A Whole Genome Sequencing was not possible for cost reasons.This sequencing will focus on the search for the mutation/mutations which is/are responsible for this disease.
Cramping episodes are a common problem in the breed. A gene defect could not yet be found. And a Whole Genome Sequencing was not possible for cost reasons.
Our aim is to support research in finding the mutation(s) responsible for this disease and therefore helping breeders to breed healthy border terriers in the future.
What is the project goal and who is the project for?
Fits/seizures/cramping episodes are a frequently occurring problem in the breed. However, a gene defect has not yet been found and for cost reasons Whole Genome Sequencing has not yet been possible.
The data obtained from the sequencing will be shared freely with various research groups.
For border terrier owners, breeders and lovers who want a healthy breed.
Why would you support this project?
Research groups worldwide are to be supported in the quest to find the mutation(s) and to develop a genetic testing. This would help breeders to breed border terriers which are not affected by this disease. We want future dogs and their owners not suffering any more.
How will we use the money if the project is successfully funded?
A Whole Genome Sequencing will be carried out, and the data obtained will be shared with all interested research groups. Researchers in the US and in the UK have already shown interest in obtaining the data. The Whole Genome Sequencing will be carried out by German lab GATC Biotech. This company is Europe’s leading sequencing services provider. If the money given exceed our goal amount, the additional money will be used for safe transportation of the DNA and of the data obtained and also for research in border terrier seizures (if the crowd is helping us in a very large scale, we could do another WGS of another border terrier with seizures as well).
Who are the people behind the project?
Dr. med vet Evalotta Sehrig-Lovén Veterinarian and since 2011 owner of a border terrier with CECS and a team of more Border Terrier owners from Germany and the Netherlands (see our website).